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Urine X-24354 levels in chronic kidney disease

CYP2C9 · rs111667734

Where this position leads

Drugs: Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin

rs111667734 Drug: Acenocoumarol and phenprocoumon Acenocoumarol and phenprocoumon Drug Drug: NSAIDs NSAIDs Drug Drug: Phenytoin and fosphenytoin Phenytoin and fosphenytoin Drug Drug: Siponimod Siponimod Drug Drug: Statins Statins Drug Drug: Sulfonylureas Sulfonylureas Drug Drug: Warfarin Warfarin Drug rs111667734 rs111667734 CYP2C9

What the study found

Who was studied 4,713 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.323 higher (95% confidence interval 0.24-0.41); p = 2 × 10−13.

How common The A allele had a frequency of about 8% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C9.

What each result means

A/A Two copies of the version the research linked to Urine X-24354 levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Urine X-24354 levels in chronic kidney disease. That is a smaller link than two copies.
G/G No copy of the version the research linked to Urine X-24354 levels in chronic kidney disease. This is the starting point the study compared everyone against.
Source
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, Steinbrenner I, Uluvar B, Wuttke M, Cheng Y, Ekici AB, Gyimesi G, Karoly ED
and 20 more — show all
Kotsis F, Mielke J, Gomez MF, Yu B, Grams ME, Coresh J, Boerwinkle E, Köttgen M, Kronenberg F, Meiselbach H, Mohney RP, Akilesh S, Schmidts M, Hediger MA, Schultheiss UT, Eckardt KU, Oefner PJ, Sekula P, Li Y, Köttgen A
GCKD Investigators
Nature genetics · 2023 · PMID 37277652 · open access

Questions about rs111667734

What is rs111667734?

rs111667734 is a single position in the genome, in or near the CYP2C9 gene. Published research associates it with urine x-24354 levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs111667734 affect how medicines work?

CYP2C9 carries pharmacogenomic findings for Acenocoumarol and phenprocoumon, NSAIDs, Phenytoin and fosphenytoin, Siponimod, Statins, Sulfonylureas, Warfarin. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs111667734 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs111667734 come from?

GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Urine X-24354 levels in chronic kidney disease (rs111667734). MyGeneLog™. https://www.mygenelog.com/variants/rs111667734

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