The same pharmacogenomics that sits on our condition pages, read from the other end. People rarely arrive asking about SLCO1B1 — they arrive having been prescribed a statin. Each page below collects what published guidelines say about one drug, names the genes involved, and links to the variants your own file would contain.
Supplements — kept apart, with the evidence stated on each →
None of this is dosing guidance. Where a clinical guideline exists it is written for prescribers, and the pages say so. Nothing here is a reason to start, stop or change a medication.
The standard starting dose was calibrated on people whose CYP3A5 does not work, because in Europe that is most people. The ones whose enzyme is intact get too little — in the first days after a transplant, when too little means rejection.
CYP3A5
See what the research says → ImmunosuppressantThis drug's own label carries a warning that runs the opposite direction from most on this site: not a dosing adjustment based on a metabolism gene, but a caution rooted in a separate, rare genetic disease -- the same one behind a severe inherited form of gout.
HPRT1
See what the research says → ImmunosuppressantAzathioprine and mercaptopurine, used in inflammatory bowel disease and leukaemia. Two genes decide how much a person can tolerate, and testing before the first dose is standard practice in many hospitals.
TPMT · NUDT15
See what the research says →The same pharmacogenomics already published on our condition pages, read from the drug side instead: what published guidelines say about one medicine, which genes are involved, and the variants your own file would contain.
No. Where a clinical guideline exists it is written for prescribers, and nothing here is a reason to start, stop or change a medication — that belongs with the clinician or pharmacist managing treatment.
Because almost nothing sold as a supplement has a prescribing guideline behind it the way a drug does, and listing the two together would lend the second the authority of the first.
By gene symbol as a whole word, gathered from the pgx_notes already published on the condition pages that discuss each drug — not a second, separate copy of that information.