0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 286 African American or Afro-Caribbean cases, 121,446 African American or Afro-Caribbean controls, 19,217 European ancestry cases, 419,674 European ancestry controls, 429 Hispanic or Latin American cases, 59,212 Hispanic or Latin American controls.
The effect
Each copy of the T allele shifted the measure 4.38 lower (95% confidence interval 4.37-4.39); p = 1 × 10−11.
How common The T allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 2, band 2p23.2 — in an intron of ALK.
What each result means
C/CNo copy of the version the research linked to Squamous cell carcinoma (PheCode 172.22). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Squamous cell carcinoma (PheCode 172.22). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Squamous cell carcinoma (PheCode 172.22). That is the strongest link of the three results. A link in a study is not a diagnosis.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs186916993
What is rs186916993?
rs186916993 is a single position in the genome, in or near the ALK gene. Published research associates it with squamous cell carcinoma (phecode 172.22). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs186916993 linked to?
On MyGeneLog this position is linked to Squamous Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs186916993 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs186916993 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 312Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others2Total3Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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