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5 conditions

Crohn's Disease A lifelong inflammatory bowel disease that can affect any part of the digestive tract. Its genetics are unusually well mapped — NOD2 was th… Knee Osteoarthritis For a century this was "wear and tear" — a joint used until it wore out. Then a scan of 4,800 people found its strongest signal in the immu… Rheumatoid Arthritis An autoimmune disease that attacks the lining of joints. The variant here sits in a small stretch of chromosome 6 that turned out to hold t… Systemic Lupus Erythematosus An autoimmune disease that can affect almost any organ, with strong genetic involvement and dozens of known loci that together still explai… Type 1 Diabetes An autoimmune disease that destroys the cells making insulin. It shares a word with type 2 diabetes and almost nothing else — different age…