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Gene

HFE

Homeostatic iron regulator

HFE helps the body decide how much iron to take in from food. Two copies of its C282Y change can let iron build up over years, which is hereditary hemochromatosis, though many people with two copies never have trouble.

Supplements that come up with it

• Iron · Mineral

Conditions it is linked to

• Autism Spectrum Disorder and Schizophrenia (Shared Genetic Risk)
• Blood Cell Counts
• Hereditary Hemochromatosis (HFE)
• Intelligence
• Irritable Mood
• Schizophrenia

Variants inside HFE (8)

• rs61472021 · Autism spectrum disorder or schizophrenia
• rs1736904 · Feeling guilty
• rs79220007 · High light scatter reticulocyte count
• rs13216785 · Intelligence (MTAG)
• rs1800562 · Iron overload risk (hereditary hemochromatosis)
• rs1799945 · Iron overload risk (HFE H63D)
• rs1800730 · Mean corpuscular hemoglobin
• rs2032451 · Mean corpuscular hemoglobin

Questions about HFE

Does one copy of HFE C282Y cause iron overload?

Usually not. One copy makes you a carrier. Iron overload is mostly seen with two copies.

How is iron overload found?

With blood tests of iron levels, which a doctor can order; a genetic test then helps explain the cause.

See HFE with everything it connects to on the Gene Knowledge Graph, or as data at /api/v1/genes/HFE.

A gene page gathers published research; it is not a test result and not medical advice. If a gene matters to your health, talk to a doctor or a genetic counsellor.