Hodgkin's Disease, as genome-wide studies have reported it: 9 positions from 1 study, the largest recording 1,190 cases and 571,426 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
This is the record of what genome-wide association studies have found for Hodgkin's Disease (the GWAS Catalog's "Hodgkin's disease (PheCode 201)"): 9 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 1,190 cases and 571,426 controls (African American or Afro-Caribbean ancestry, European ancestry). It contributes 9 positions: rs559464313 (DRD4), rs532391514 (near PLA2G4A), rs75229018 (near LINC02838), rs138809598 (LINC02737), rs565643303 (TTL), rs377333979 (RNF141), rs547573644 (near LPAR1), rs1047391271 (NFIX), and 1 more. PMID:39024449.
The 9 positions sit in or beside 9 genes: DRD4, PLA2G4A, LINC02838, LINC02737, TTL, RNF141, LPAR1, NFIX, GALNTL5. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs559464313 in DRD4, reported by Verma A et al. 2024 at P = 2 × 10-13.
It is a record of what genome-wide studies have reported about Hodgkin's Disease, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Hodgkin's Disease. The 9 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Hodgkin's Disease comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Hodgkin's Disease. MyGeneLog™. https://www.mygenelog.com/conditions/hodgkins-disease
Hodgkin's Disease is the condition the GWAS Catalog files under "Hodgkin's disease (PheCode 201)". This page does not define it in its own words; it lists what genome-wide studies have reported: 9 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 9 associated positions; the largest study behind this page recorded 1,190 cases and 571,426 controls (African American or Afro-Caribbean ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 9 genes: DRD4, PLA2G4A, LINC02838, LINC02737, TTL, RNF141, LPAR1, NFIX, GALNTL5. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Hodgkin's Disease from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.