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Who was studied 215 African American or Afro-Caribbean cases, 121,633 African American or Afro-Caribbean controls, 975 European ancestry cases, 449,793 European ancestry controls.
The effect
Each copy of the C allele shifted the measure 2.78 lower (95% confidence interval 2.74-2.81); p = 4 × 10−11.
How common The C allele had a frequency of about 100% in the people studied.
Where it sits Chromosome 17, band 17p11.2 — between genes, 4.7 kb from SHMT1.
What each result means
C/CPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hodgkin's disease (PheCode 201) compared to the general population.
C/GPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hodgkin's disease (PheCode 201).
G/GPublished research associates this genotype with typical/baseline likelihood of Hodgkin's disease (PheCode 201) — no copies of the reported risk allele.
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access
Questions about rs181755438
What is rs181755438?
rs181755438 is a single position in the genome, in or near the near SHMT1 gene. Published research associates it with hodgkin's disease (phecode 201). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs181755438 linked to?
On MyGeneLog this position is linked to Hodgkin's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs181755438 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs181755438 come from?
GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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