Corneal Astigmatism, as genome-wide studies have reported it: 4 positions from 2 studies, the largest recording 69,140 cases and 17,195 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Genome-wide studies have so far placed 4 positions on Corneal Astigmatism, from 2 studies; the GWAS Catalog files the condition as "Corneal astigmatism". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Shah RL et al. 2018, in Human Genetics — Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci. The catalogue records its sample as 69,140 cases and 17,195 controls (European ancestry). From it, 3 positions on this page: rs62075722 (TSPAN10), rs12196123 (LINC00340), rs72629670 (ZC3H11B). PMID:30306274.
Fan Q et al. 2011, in PLoS Genetics — Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism. Studied in 2,249 cases and 2,005 controls (Chinese ancestry). It contributes one position: rs7677751 (PDGFRA). PMID:22144915.
The 4 positions lie in or near 4 genes: TSPAN10, LINC00340, ZC3H11B, PDGFRA. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs62075722 in TSPAN10, reported by Shah RL et al. 2018 at P = 2 × 10-13.
Read this page as a list of findings about Corneal Astigmatism, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Corneal Astigmatism. The 4 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Corneal Astigmatism comes down to these specific, well-studied positions — not a diagnosis.
The studies behind these variants recruited participants from different ancestries — a result found in one population doesn't always transfer to another. Based on 4 of 4 linked studies with a resolved discovery ancestry.
Databases, guidelines and references
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Corneal Astigmatism. MyGeneLog™. https://www.mygenelog.com/conditions/corneal-astigmatism
Corneal Astigmatism is the condition the GWAS Catalog files under "Corneal astigmatism". This page does not define it in its own words; it lists what genome-wide studies have reported: 4 positions from 2 studies, with each study's sample and citation.
Genome-wide studies have reported 4 associated positions; the largest study behind this page recorded 69,140 cases and 17,195 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 4 genes: TSPAN10, LINC00340, ZC3H11B, PDGFRA. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Corneal Astigmatism is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.