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Corneal astigmatism

ZC3H11B · rs72629670

Where this position leads

Condition: Corneal Astigmatism

rs72629670 Condition: Corneal Astigmatism Corneal Astigmatism Condition rs72629670 rs72629670 ZC3H11B

What the study found

Who was studied 69,140 European ancestry cases, 17,195 European ancestry controls.

The effect Each copy of the A allele carried 1.08 times the odds of Corneal astigmatism (95% confidence interval 1.05-1.11); p = 4 × 10−10.

Where it sits Chromosome 1, band 1q41 — between genes, 13.2 kb from ZC3H11B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Corneal astigmatism compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Corneal astigmatism.
G/G Published research associates this genotype with typical/baseline likelihood of Corneal astigmatism — no copies of the reported risk allele.
Source
Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci
Shah RL, Guggenheim JA
UK Biobank Eye and Vision Consortium
Human genetics · 2018 · PMID 30306274 · open access

Questions about rs72629670

What is rs72629670?

rs72629670 is a single position in the genome, in or near the ZC3H11B gene. Published research associates it with corneal astigmatism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs72629670 linked to?

On MyGeneLog this position is linked to Corneal Astigmatism. The research behind each link, and its sources, are set out on that condition page.

Does having rs72629670 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs72629670 come from?

GWAS Catalog, Hum Genet 2018, PMID:30306274. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Corneal astigmatism (rs72629670). MyGeneLog™. https://www.mygenelog.com/variants/rs72629670

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