LINC00340 · rs12196123
Where this position leads
Condition: Corneal Astigmatism
What the study found
Who was studied 88,005 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.022 dioptres lower (95% confidence interval 0.016-0.028); p = 1 × 10−11.
Where it sits Chromosome 6, band 6p22.3 — in an intron of CASC15.
rs12196123 is a single position in the genome, in or near the LINC00340 gene. Published research associates it with refractive astigmatism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Corneal Astigmatism. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Genet 2018, PMID:30306274. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Refractive astigmatism (rs12196123). MyGeneLog™. https://www.mygenelog.com/variants/rs12196123