Gene Knowledge Graph
UTC
Standard

Corneal astigmatism

TSPAN10 · rs62075722

Where this position leads

Condition: Corneal Astigmatism

rs62075722 Condition: Corneal Astigmatism Corneal Astigmatism Condition rs62075722 rs62075722 TSPAN10

What the study found

Who was studied Up to 86,335 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.022 dioptres higher (95% confidence interval 0.016-0.028); p = 2 × 10−13.

How common The A allele had a frequency of about 36% in the people studied.

Where it sits Chromosome 17, band 17q25.3 — in an intron of TSPAN10.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Corneal astigmatism compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Corneal astigmatism.
G/G Published research associates this genotype with typical/baseline likelihood of Corneal astigmatism — no copies of the reported risk allele.
Source
Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci
Shah RL, Guggenheim JA
UK Biobank Eye and Vision Consortium
Human genetics · 2018 · PMID 30306274 · open access

Questions about rs62075722

What is rs62075722?

rs62075722 is a single position in the genome, in or near the TSPAN10 gene. Published research associates it with corneal astigmatism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs62075722 linked to?

On MyGeneLog this position is linked to Corneal Astigmatism. The research behind each link, and its sources, are set out on that condition page.

Does having rs62075722 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs62075722 come from?

GWAS Catalog, Hum Genet 2018, PMID:30306274. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Corneal astigmatism (rs62075722). MyGeneLog™. https://www.mygenelog.com/variants/rs62075722

← See all variants