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Corneal astigmatism

PDGFRA · rs7677751

Where this position leads

What the study found

Who was studied 1,231 Chinese ancestry cases, 785 Chinese ancestry controls, 1,018 Malay ancestry cases, 1,220 Malay ancestry controls; replicated in 825 Indian ancestry cases, 1,314 Indian ancestry controls, 760 Chinese ancestry child cases, 169 Chinese ancestry child controls, 397 Chinese ancestry trios.

The effect Each copy of the T allele carried 1.26 times the odds of Corneal astigmatism (95% confidence interval 1.18-1.34); p = 8 × 10⁻⁹.

How common The T allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 4, band 4q12 — in an intron of PDGFRA.

What each result means

C/C No copy of the version the research linked to Corneal astigmatism. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Corneal astigmatism. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Corneal astigmatism. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism

Fan Q, Zhou X, Khor CC, Cheng CY, Goh LK, Sim X, Tay WT, Li YJ, Ong RT, Suo C, Cornes B, Ikram MK

and 10 more — show all

Chia KS, Seielstad M, Liu J, Vithana E, Young TL, Tai ES, Wong TY, Aung T, Teo YY, Saw SM

PLoS genetics · 2011 · PMID 22144915 · open access

What people read about alongside this

Short-sightedness and screens2

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs7677751

What is rs7677751?

rs7677751 is a single position in the genome, in or near the PDGFRA gene. Published research associates it with corneal astigmatism. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7677751 linked to?

On MyGeneLog this position is linked to Corneal Astigmatism. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs7677751?

Subjects that appear in the title or abstract of the same papers as this rsID include short-sightedness and screens (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs7677751 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7677751 come from?

GWAS Catalog, PLoS Genet 2011, PMID:22144915. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Corneal astigmatism (rs7677751). MyGeneLog™. https://www.mygenelog.com/variants/rs7677751

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