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Linoleic acid to total fatty acids percentage

CYP2C19 · rs9888067

Where this position leads

Condition: Cholesterol (LDL, HDL and Total)

Drugs: Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole

rs9888067 Condition: Cholesterol (LDL, HDL and Total) Cholesterol (LDL, HDL and Total) Condition Drug: Brivaracetam Brivaracetam Drug Drug: Clopidogrel Clopidogrel Drug Drug: Proton pump inhibitors Proton pump inhibitors Drug Drug: Serotonin reuptake antidepressants Serotonin reuptake antidepressants Drug Drug: Voriconazole Voriconazole Drug rs9888067 rs9888067 CYP2C19

What the study found

Who was studied 434,646 British ancestry individuals, 8,796 British Central/South Asian individuals, 6,573 British African individuals.

The effect Each copy of the G allele shifted the measure 0.02 % higher (95% confidence interval 0.02-0.02); p = 7 × 10−12.

Where it sits Chromosome 10, band 10q23.33 — between genes, 5.1 kb from RPL7AP52.

What each result means

G/G Two copies of the version the research linked to Linoleic acid to total fatty acids percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Linoleic acid to total fatty acids percentage. That is a smaller link than two copies.
T/T No copy of the version the research linked to Linoleic acid to total fatty acids percentage. This is the starting point the study compared everyone against.
Source

Questions about rs9888067

What is rs9888067?

rs9888067 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with linoleic acid to total fatty acids percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9888067 linked to?

On MyGeneLog this position is linked to Cholesterol (LDL, HDL and Total). The research behind each link, and its sources, are set out on that condition page.

Does rs9888067 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9888067 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9888067 come from?

GWAS Catalog, Nature genetics 2025, PMID:41044249. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Linoleic acid to total fatty acids percentage (rs9888067). MyGeneLog™. https://www.mygenelog.com/variants/rs9888067

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