Sensitive

DPYD HapB3 — fluoropyrimidine tolerance

DPYD · rs75017182

Where this position leads

Drug: Fluoropyrimidines

rs75017182 Drug: Fluoropyrimidines Fluoropyrimidines Drug rs75017182 rs75017182 DPYD

What each result means

C/C Two copies of HapB3, with correspondingly lower activity and a larger dose reduction.
C/G One copy of DPYD HapB3, an intronic variant that causes part of the message to be spliced wrongly and leaves reduced enzyme activity. CPIC treats it as decreased function with a reduced starting dose.
G/G No copy of the HapB3 haplotype at this position.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.

Source: CPIC Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update, Clinical Pharmacology & Therapeutics (PMID 29152729).

Questions about rs75017182

What is rs75017182?

rs75017182 is a single position in the genome, in or near the DPYD gene. Published research associates it with dpyd hapb3 — fluoropyrimidine tolerance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs75017182 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs75017182 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs75017182 come from?

CPIC Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update, Clinical Pharmacology & Therapeutics (PMID 29152729). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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