DPYD · rs75017182
What ClinVar records
Classification
drug response for capecitabine response - Toxicity, fluorouracil response - Toxicity, fluorouracil response - Other, DPYD-related disorder; reviewed by expert panel (3 of 4 stars, 3 submitters), last evaluated 2022-10-27.
ClinVar record 635263 NM_000110.4(DPYD):c.1129-5923C>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
2026-07-09 · CPIC (ClinPGx blog)
CPIC Comment on Pending DPYD Guideline Update
CPIC previewed a coming change to its DPYD/fluoropyrimidine guideline (the finalized version is still expected later in 2026, not yet published): the HapB3 variant this page already profiles (rs75017182, c.1129-5923C>G) will be assigned a formal activity value of 0.75 -- for a heterozygous carrier, an activity score of 1.75, with CPIC recommending starting fluoropyrimidine chemotherapy at 75% of the intended dose in the first cycle rather than full dose, then escalating based on tolerability. This is CPIC's own announced plan, not yet the finalized guideline -- flagged here as pending, not settled.
rs75017182 is a single position in the genome, in or near the DPYD gene. Published research associates it with dpyd hapb3 — fluoropyrimidine tolerance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Fluoropyrimidine Dosing (DPYD). The research behind each link, and its sources, are set out on that condition page.
DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
CPIC Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update, Clinical Pharmacology & Therapeutics (PMID 29152729). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
DPYD HapB3 — fluoropyrimidine tolerance (rs75017182). MyGeneLog™. https://www.mygenelog.com/variants/rs75017182