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Who was studied 98,316 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.132 lower (95% confidence interval 0.098-0.166); p = 1 × 10−14.
How common The C allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.
What each result means
C/CTwo copies of the version the research linked to Cholesterol to Total Lipids in IDL percentage. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Cholesterol to Total Lipids in IDL percentage. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Cholesterol to Total Lipids in IDL percentage. This is the starting point the study compared everyone against.
Ophthalmology science · 2024 · PMID 39091897 · open access
Questions about rs62396278
What is rs62396278?
rs62396278 is a single position in the genome, in or near the HLA-B gene. Published research associates it with cholesterol to total lipids in idl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs62396278 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does rs62396278 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs62396278 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs62396278 come from?
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
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Cholesterol to Total Lipids in IDL percentage (rs62396278). MyGeneLog™. https://www.mygenelog.com/variants/rs62396278