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Lymphocyte count

CYP2C19 · rs58667319

Where this position leads

Drugs: Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole

What the study found

Who was studied 524,923 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.0232 SD unit lower (95% confidence interval 0.018-0.029); p = 1 × 10⁻¹⁵.

How common The T allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — in an intron of CYP2C19.

What each result means

C/C No copy of the version the research linked to Lymphocyte count. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Lymphocyte count. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Lymphocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations

Chen MH, Raffield LM, Mousas A, Sakaue S, Huffman JE, Moscati A, Trivedi B, Jiang T, Akbari P, Vuckovic D, Bao EL, Zhong X

and 98 more — show all

Manansala R, Laplante V, Chen M, Lo KS, Qian H, Lareau CA, Beaudoin M, Hunt KA, Akiyama M, Bartz TM, Ben-Shlomo Y, Beswick A, Bork-Jensen J, Bottinger EP, Brody JA, van Rooij FJA, Chitrala K, Cho K, Choquet H, Correa A, Danesh J, Di Angelantonio E, Dimou N, Ding J, Elliott P, Esko T, Evans MK, Floyd JS, Broer L, Grarup N, Guo MH, Greinacher A, Haessler J, Hansen T, Howson JMM, Huang QQ, Huang W, Jorgenson E, Kacprowski T, Kähönen M, Kamatani Y, Kanai M, Karthikeyan S, Koskeridis F, Lange LA, Lehtimäki T, Lerch MM, Linneberg A, Liu Y, Lyytikäinen LP, Manichaikul A, Martin HC, Matsuda K, Mohlke KL, Mononen N, Murakami Y, Nadkarni GN, Nauck M, Nikus K, Ouwehand WH, Pankratz N, Pedersen O, Preuss M, Psaty BM, Raitakari OT, Roberts DJ, Rich SS, Rodriguez BAT, Rosen JD, Rotter JI, Schubert P, Spracklen CN, Surendran P, Tang H, Tardif JC, Trembath RC, Ghanbari M, Völker U, Völzke H, Watkins NA, Zonderman AB, Wilson PWF, Li Y, Butterworth AS, Gauchat JF, Chiang CWK, Li B, Loos RJF, Astle WJ, Evangelou E, van Heel DA, Sankaran VG, Okada Y, Soranzo N, Johnson AD, Reiner AP, Auer PL, Lettre G

VA Million Veteran Program

Cell · 2020 · PMID 32888493

Questions about rs58667319

What is rs58667319?

rs58667319 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with lymphocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs58667319 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs58667319 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs58667319 come from?

GWAS Catalog, Cell 2020, PMID:32888493. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lymphocyte count (rs58667319). MyGeneLog™. https://www.mygenelog.com/variants/rs58667319

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