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Urine glucuronide of C14H22O4 (3)* levels in chronic kidney disease

CYP2C19 · rs57991629

Where this position leads

Drugs: Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole

rs57991629 Drug: Brivaracetam Brivaracetam Drug Drug: Clopidogrel Clopidogrel Drug Drug: Proton pump inhibitors Proton pump inhibitors Drug Drug: Serotonin reuptake antidepressants Serotonin reuptake antidepressants Drug Drug: Voriconazole Voriconazole Drug rs57991629 rs57991629 CYP2C19

What the study found

Who was studied 3,996 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.298 lower (95% confidence interval 0.24-0.36); p = 3 × 10−23.

How common The C allele had a frequency of about 19% in the people studied.

Where it sits Chromosome 10, band 10q23.33 — between genes, 26.3 kb from RPL7AP52.

What each result means

C/C Two copies of the version the research linked to Urine glucuronide of C14H22O4 (3)* levels in chronic kidney disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Urine glucuronide of C14H22O4 (3)* levels in chronic kidney disease. That is a smaller link than two copies.
T/T No copy of the version the research linked to Urine glucuronide of C14H22O4 (3)* levels in chronic kidney disease. This is the starting point the study compared everyone against.
Source
Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine
Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, Steinbrenner I, Uluvar B, Wuttke M, Cheng Y, Ekici AB, Gyimesi G, Karoly ED
and 20 more — show all
Kotsis F, Mielke J, Gomez MF, Yu B, Grams ME, Coresh J, Boerwinkle E, Köttgen M, Kronenberg F, Meiselbach H, Mohney RP, Akilesh S, Schmidts M, Hediger MA, Schultheiss UT, Eckardt KU, Oefner PJ, Sekula P, Li Y, Köttgen A
GCKD Investigators
Nature genetics · 2023 · PMID 37277652 · open access

Questions about rs57991629

What is rs57991629?

rs57991629 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with urine glucuronide of c14h22o4 (3)* levels in chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs57991629 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Brivaracetam, Clopidogrel, Proton pump inhibitors, Serotonin reuptake antidepressants, Voriconazole. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs57991629 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs57991629 come from?

GWAS Catalog, Nature genetics 2023, PMID:37277652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Urine glucuronide of C14H22O4 (3)* levels in chronic kidney disease (rs57991629). MyGeneLog™. https://www.mygenelog.com/variants/rs57991629

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