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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.328 lower (95% confidence interval 0.23-0.43); p = 5 × 10−12.
How common The T allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 18, band 18q12.1 — a missense change in TTR.
What each result means
C/CNo copy of the version the research linked to TTR protein levels. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to TTR protein levels. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to TTR protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs28933981
What is rs28933981?
rs28933981 is a single position in the genome, in or near the TTR gene. Published research associates it with ttr protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs28933981 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs28933981 affect how medicines work?
TTR carries pharmacogenomic findings for Acoramidis (Attruby), Tafamidis (Vyndaqel, Vyndamax), Vutrisiran (Amvuttra). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs28933981 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs28933981 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 4112Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon1Apple0China (ByteDance, Huawei, Baidu…)0Others2Total4Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
TTR protein levels (rs28933981). MyGeneLog™. https://www.mygenelog.com/variants/rs28933981