TTR stabiliser

Acoramidis (Attruby)

Another way to hold transthyretin together: a newer pill, taken twice a day, for the heart form of ATTR, hereditary or not.

What this drug connects to

The genes involved

TTR

Transthyretin Amyloidosis (ATTR) →

Acoramidis (Attruby) is also a stabiliser, a pill taken twice a day, approved in the US in 2024 for the heart form of ATTR, wild-type or hereditary. In its main trial of 632 patients over 30 months, it did better than placebo on a combined measure of death, heart-related hospital stays and heart function. Whether to take it is decided with a specialist, and nothing here is a reason to start, stop or change a medicine.

ATTRibute-CM (Gillmore JD et al., NEJM 2024, PMID 38197816); ATTRUBY US prescribing information, revised 6/2026 (DailyMed).

Variants MyGeneLog™ reports for these genes

These are the positions in your own file that carry the genes above. Not every gene in a guideline is one we report — where that is the case the gene appears above without a variant here, and the note says so.

Retinol-binding protein 4 levels

TTR · rs1791209

TTR protein levels

TTR · rs28933981

MEP1B protein levels

TTR · rs528071310

Metabolite peak levels (QI722)

TTR · rs76992529

Questions about Acoramidis (Attruby)

What is acoramidis?

Acoramidis, sold as Attruby, is a pill taken twice a day for the heart form of transthyretin amyloidosis (ATTR). Like tafamidis, it holds transthyretin together so it cannot fall apart and build up in the heart.

Does my genotype decide whether I can take acoramidis?

No. It was approved in the US in 2024 for the heart form of ATTR, wild-type or hereditary.

How well does acoramidis work?

In its main trial, 632 patients were followed for 30 months, and it did better than placebo on a combined measure of death, heart-related hospital stays and heart function. Whether to take it is decided with a specialist; nothing here is a reason to start, stop or change a medicine.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Acoramidis (Attruby). MyGeneLog™. https://www.mygenelog.com/drugs/acoramidis

This page is educational and contains no dosing information. Where a clinical guideline covers one of these gene-drug pairs it is written for prescribers and works through validated algorithms alongside clinical monitoring. Nothing here is a reason to start, stop, or change a medication — that conversation belongs with the clinician or pharmacist managing your treatment.