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Retinol-binding protein 4 levels

TTR · rs1791209

Where this position leads

Drugs: Acoramidis (Attruby), Tafamidis (Vyndaqel, Vyndamax), Vutrisiran (Amvuttra)

rs1791209 Drug: Acoramidis (Attruby) Acoramidis (Attruby) Drug Drug: Tafamidis (Vyndaqel, Vyndamax) Tafamidis (Vyndaqel, Vyndamax) Drug Drug: Vutrisiran (Amvuttra) Vutrisiran (Amvuttra) Drug rs1791209 rs1791209 TTR

What the study found

Who was studied 10,708 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.091 higher (95% confidence interval 0.066-0.116); p = 8 × 10−13.

How common The T allele had a frequency of about 54% in the people studied.

Where it sits Chromosome 18, band 18q12.1 — in an intron of TTR.

What each result means

G/G No copy of the version the research linked to Retinol-binding protein 4 levels. This is the starting point the study compared everyone against.
G/T One copy of the version the research linked to Retinol-binding protein 4 levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to Retinol-binding protein 4 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs1791209

What is rs1791209?

rs1791209 is a single position in the genome, in or near the TTR gene. Published research associates it with retinol-binding protein 4 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs1791209 affect how medicines work?

TTR carries pharmacogenomic findings for Acoramidis (Attruby), Tafamidis (Vyndaqel, Vyndamax), Vutrisiran (Amvuttra). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs1791209 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1791209 come from?

GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Retinol-binding protein 4 levels (rs1791209). MyGeneLog™. https://www.mygenelog.com/variants/rs1791209

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