Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What each result means
C/CThe reference base at this position. On its own this does not rule out G6PD deficiency: more than two hundred deficiency-causing variants are known and consumer genotyping covers only a few of the most common ones.
C/TOne copy of the variant allele. G6PD sits on the X chromosome, so what this means depends on sex. In a female this is the carrier state and enzyme activity varies widely between individuals because of X-inactivation — a heterozygous female cannot be assigned a phenotype from genotype alone, and some are functionally deficient. A male has only one X, so a genotype reported this way in a male usually reflects how the array calls a single copy rather than two different ones.
T/TTwo copies of the variant allele, or one copy in a male. This is the G6PD A- allele, the most common deficiency allele in people of African ancestry, and it produces reduced enzyme activity. It matters for a specific list of medicines and for fava beans, and not for daily life otherwise.
G6PD deficiency is diagnosed by measuring enzyme activity, not by reading a genotype file, and the measurement can read falsely normal during or just after an episode of haemolysis. If this is relevant to you, ask for the enzyme test.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1050828
What is rs1050828?
rs1050828 is a single position in the genome, in or near the G6PD gene. Published research associates it with g6pd deficiency (g6pd a-). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1050828 linked to?
On MyGeneLog this position is linked to G6PD Deficiency. The research behind each link, and its sources, are set out on that condition page.
Does rs1050828 affect how medicines work?
G6PD carries pharmacogenomic findings for Dapsone, nitrofurantoin and other oxidising drugs, Primaquine and tafenoquine, Rasburicase. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
What do people read about alongside rs1050828?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (4 papers), longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1050828 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1050828 come from?
CPIC Guideline for G6PD Genotype and Medication Use (Clin Pharmacol Ther 2023, PMID 36049896). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.