Lumbar Disc Herniation, as genome-wide studies have reported it: 10 positions from 1 study, the largest recording 80,724 cases and 748,975 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
This is the record of what genome-wide association studies have found for Lumbar Disc Herniation (the GWAS Catalog's "Lumbar disc herniation"): 10 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Salo V et al. 2024, in Nature Communications — Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations. Studied in 80,724 cases and 748,975 controls (European ancestry). From it, 10 positions on this page: rs11831278 (SOX5), rs9787942 (LINC02751), rs3849386 (TGFA), rs3010043 (COLGALT2), rs11848465 (SLC25A21), rs2224214 (near TBX18), rs58723578 (near BARX1), rs10227463 (STX1A), and 2 more. PMID:39511132.
The 10 positions lie in or near 10 genes: SOX5, LINC02751, TGFA, COLGALT2, SLC25A21, TBX18, BARX1, STX1A, CNOT4, PPP4R2. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Salo V et al. 2024 reported the smallest P value on this page — P = 4 × 10-26, with an odds ratio of 1.09 — at rs11831278 in SOX5.
It is a record of what genome-wide studies have reported about Lumbar Disc Herniation, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Lumbar Disc Herniation is diagnosed by a clinician — not from a genotype. None of the 10 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Lumbar Disc Herniation comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Lumbar Disc Herniation. MyGeneLog™. https://www.mygenelog.com/conditions/lumbar-disc-herniation
Lumbar Disc Herniation is the condition the GWAS Catalog files under "Lumbar disc herniation". This page does not define it in its own words; it lists what genome-wide studies have reported: 10 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 10 associated positions; the largest study behind this page recorded 80,724 cases and 748,975 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 10 genes: SOX5, LINC02751, TGFA, COLGALT2, SLC25A21, TBX18, BARX1, STX1A, CNOT4, PPP4R2. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Lumbar Disc Herniation from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.