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Who was studied 80,724 European ancestry cases, 748,975 European ancestry controls.
The effect
Each copy of the T allele carried 0.95 times the odds of Lumbar disc herniation (95% confidence interval 0.94-0.96); p = 4 × 10−13.
How common The T allele had a frequency of about 22% in the people studied.
Where it sits Chromosome 14, band 14q13.3 — in an intron of SLC25A21.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Lumbar disc herniation — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lumbar disc herniation.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lumbar disc herniation compared to the general population.
Nature communications · 2024 · PMID 39511132 · open access
Questions about rs11848465
What is rs11848465?
rs11848465 is a single position in the genome, in or near the SLC25A21 gene. Published research associates it with lumbar disc herniation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11848465 linked to?
On MyGeneLog this position is linked to Lumbar Disc Herniation. The research behind each link, and its sources, are set out on that condition page.
Does having rs11848465 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11848465 come from?
GWAS Catalog, Nature communications 2024, PMID:39511132. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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