6 3122162315Reads by AI crawlersClaude0ChatGPT2Google · Gemini2Perplexity1Meta AI6Microsoft · Copilot0Amazon2Apple3Others15Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 80,724 European ancestry cases, 748,975 European ancestry controls.
The effect
Each copy of the T allele carried 0.97 times the odds of Lumbar disc herniation (95% confidence interval 0.96-0.98); p = 5 × 10−8.
How common The T allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 3, band 3p13 — between genes, 17.7 kb from GPATCH11P1.
What each result means
C/CPublished research associates this genotype with typical/baseline likelihood of Lumbar disc herniation — no copies of the reported risk allele.
C/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with Lumbar disc herniation.
T/TPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Lumbar disc herniation compared to the general population.
Nature communications · 2024 · PMID 39511132 · open access
Questions about rs11914834
What is rs11914834?
rs11914834 is a single position in the genome, in or near the near PPP4R2 gene. Published research associates it with lumbar disc herniation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11914834 linked to?
On MyGeneLog this position is linked to Lumbar Disc Herniation. The research behind each link, and its sources, are set out on that condition page.
Does having rs11914834 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11914834 come from?
GWAS Catalog, Nature communications 2024, PMID:39511132. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
6 3122162315Reads by AI crawlersClaude0ChatGPT2Google · Gemini2Perplexity1Meta AI6Microsoft · Copilot0Amazon2Apple3Others15Total31Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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