Irritable Bowel Syndrome, as genome-wide studies have reported it: 6 positions from 3 studies, the largest recording 68,267 cases and 860,556 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Irritable Bowel Syndrome — filed in the GWAS Catalog as "Irritable bowel syndrome" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 6 positions from 3 studies, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Di Lorenzo B et al. 2026, in Gut — Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms. Sample in the catalogue's record: 516,865 individuals (European ancestry). From it, 3 positions on this page: rs2195110 (PCSK2), rs72700810 (FALEC), rs10184811 (TANK-AS1). PMID:42425734.
Ye W et al. 2026, in Frontiers in Psychiatry — Large-scale meta- and cross-trait analyses uncover shared genetic risk factors for IBS and psychiatric disorders. Studied in 68,267 cases and 860,556 controls (European ancestry). It contributes 2 positions: rs7106434 (NCAM1), rs20551 (EP300). PMID:42221328.
Bonfiglio F et al. 2018, in Gastroenterology — Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome. Studied in 9,576 cases and 336,499 controls. The one position on this page from it: rs10512344 (LINC01505). PMID:29626450.
The catalogue maps the 6 positions to 6 genes: PCSK2, FALEC, TANK-AS1, NCAM1, EP300, LINC01505. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Ye W et al. 2026 reported the smallest P value on this page — P = 5 × 10-14 — at rs7106434 in NCAM1.
It is a record of what genome-wide studies have reported about Irritable Bowel Syndrome, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Irritable Bowel Syndrome; a clinician does. No guideline uses the 6 variants on this page to predict it, screen for it or confirm it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Irritable Bowel Syndrome comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Irritable Bowel Syndrome. MyGeneLog™. https://www.mygenelog.com/conditions/irritable-bowel-syndrome
Irritable Bowel Syndrome is the condition the GWAS Catalog files under "Irritable bowel syndrome". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 3 studies, with each study's sample and citation.
Genes play a part: 6 positions have been linked to it, the largest study recording 68,267 cases and 860,556 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 6 genes: PCSK2, FALEC, TANK-AS1, NCAM1, EP300, LINC01505. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Irritable Bowel Syndrome from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.