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Irritable bowel syndrome

LINC01505 · rs10512344

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 7,130 British ancestry women cases, 2,446 British ancestry men cases, 178,076 British ancestry women controls, 158,423 British ancestry men controls.

The effect Each copy of the C allele shifted the measure 0.245 higher (95% confidence interval 0.17-0.32); p = 4 × 10−10.

How common The C allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 9, band 9q31.2 — in an intron of LINC01505.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Irritable bowel syndrome compared to the general population.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Irritable bowel syndrome.
G/G Published research associates this genotype with typical/baseline likelihood of Irritable bowel syndrome — no copies of the reported risk allele.
Source
Female-Specific Association Between Variants on Chromosome 9 and Self-Reported Diagnosis of Irritable Bowel Syndrome
Bonfiglio F, Zheng T, Garcia-Etxebarria K, Hadizadeh F, Bujanda L, Bresso F, Agreus L, Andreasson A, Dlugosz A, Lindberg G, Schmidt PT, Karling P
and 24 more — show all
Ohlsson B, Simren M, Walter S, Nardone G, Cuomo R, Usai-Satta P, Galeazzi F, Neri M, Portincasa P, Bellini M, Barbara G, Latiano A, Hübenthal M, Thijs V, Netea MG, Jonkers D, Chang L, Mayer EA, Wouters MM, Boeckxstaens G, Camilleri M, Franke A, Zhernakova A, D'Amato M
Gastroenterology · 2018 · PMID 29626450

Questions about rs10512344

What is rs10512344?

rs10512344 is a single position in the genome, in or near the LINC01505 gene. Published research associates it with irritable bowel syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs10512344 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10512344 come from?

GWAS Catalog, Gastroenterology 2018, PMID:29626450. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Irritable bowel syndrome (rs10512344). MyGeneLog™. https://www.mygenelog.com/variants/rs10512344

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