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Who was studied 516,865 European ancestry individuals.
The effect
Each copy of the T allele carried 1.02 times the odds of Irritable bowel syndrome (MTAG) (95% confidence interval 1.011-1.021); p = 1 × 10−10.
How common The T allele had a frequency of about 18% in the people studied.
Where it sits Chromosome 20, band 20p12.1 — in an intron of PCSK2.
What each result means
C/CNo copy of the version the research linked to Irritable bowel syndrome (MTAG). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Irritable bowel syndrome (MTAG). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Irritable bowel syndrome (MTAG). That is the strongest link of the three results. A link in a study is not a diagnosis.
rs2195110 is a single position in the genome, in or near the PCSK2 gene. Published research associates it with irritable bowel syndrome (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs2195110 linked to?
On MyGeneLog this position is linked to Irritable Bowel Syndrome. The research behind each link, and its sources, are set out on that condition page.
Does having rs2195110 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2195110 come from?
GWAS Catalog, Gut 2026, PMID:42425734. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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