Fuchs's Corneal Dystrophy, as genome-wide studies have reported it: 6 positions from 1 study, the largest recording 3,655 cases and 254,909 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 6 positions on Fuchs's Corneal Dystrophy, from 1 study; the GWAS Catalog files the condition as "Fuchs's corneal dystrophy". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Gorman BR et al. 2024, in Communications Biology — A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation. Sample in the catalogue's record: 3,655 cases and 254,909 controls (European ancestry). From it, 6 positions on this page: rs79742895 (KANK4), rs2093985 (LAMC1), rs11590557 (SSBP3), rs74882680 (THSD7A), rs114065856 (COL18A1), rs141208202 (LAMA5). PMID:38582945.
The 6 positions sit in or beside 6 genes: KANK4, LAMC1, SSBP3, THSD7A, COL18A1, LAMA5. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Of all these, rs79742895 in KANK4 carries the strongest signal: P = 2 × 10-24, with an odds ratio of 1.78, in Gorman BR et al. 2024.
Read this page as a list of findings about Fuchs's Corneal Dystrophy, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Fuchs's Corneal Dystrophy. The 6 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Fuchs's Corneal Dystrophy comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Fuchs's Corneal Dystrophy. MyGeneLog™. https://www.mygenelog.com/conditions/fuchss-corneal-dystrophy
In the GWAS Catalog, Fuchs's Corneal Dystrophy is filed as "Fuchs's corneal dystrophy". Rather than define it, this page lists the genome-wide findings: 6 positions from 1 study, each with its study's sample and citation.
Genes play a part: 6 positions have been linked to it, the largest study recording 3,655 cases and 254,909 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 6 genes: KANK4, LAMC1, SSBP3, THSD7A, COL18A1, LAMA5. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Fuchs's Corneal Dystrophy from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.