LAMC1 · rs2093985
Where this position leads
Condition: Fuchs's Corneal Dystrophy
What the study found
Who was studied 3,655 European ancestry cases, 254,909 European ancestry controls, 315 admixed African ancestry cases, 78,885 admixed African ancestry controls.
The effect Each copy of the T allele carried 0.80 times the odds of Fuchs's corneal dystrophy (95% confidence interval 0.76473-0.84379); p = 3 × 10−18.
How common The T allele had a frequency of about 54% in the people studied.
Where it sits Chromosome 1, band 1q25.3 — in an intron of LAMC1.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2021-05-12.
ClinVar record 1221045 NM_002293.4(LAMC1):c.2648-210C>T
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2093985 is a single position in the genome, in or near the LAMC1 gene. Published research associates it with fuchs's corneal dystrophy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Fuchs's Corneal Dystrophy. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications biology 2024, PMID:38582945. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Fuchs's corneal dystrophy (rs2093985). MyGeneLog™. https://www.mygenelog.com/variants/rs2093985