LAMA5 · rs141208202
Where this position leads
Condition: Fuchs's Corneal Dystrophy
What the study found
Who was studied 3,655 European ancestry cases, 254,909 European ancestry controls.
The effect Each copy of the T allele carried 1.40 times the odds of Fuchs's corneal dystrophy (95% confidence interval 1.24555-1.57072); p = 1 × 10−8.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 20, band 20q13.33 — a missense change in LAMA5.
What ClinVar records
Classification
Benign for Cervical cancer, Clear cell carcinoma of kidney, Uveal melanoma, Colon adenocarcinoma, Sarcoma and 5 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 4 submitters), last evaluated 2026-01-30.
ClinVar record 1600443 NM_005560.6(LAMA5):c.6467G>A (p.Gly2156Glu)
What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs141208202 is a single position in the genome, in or near the LAMA5 gene. Published research associates it with fuchs's corneal dystrophy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Fuchs's Corneal Dystrophy. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Communications biology 2024, PMID:38582945. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Fuchs's corneal dystrophy (rs141208202). MyGeneLog™. https://www.mygenelog.com/variants/rs141208202