Dyshidrosis, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 2,455 cases and 626,220 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
This is the record of what genome-wide association studies have found for Dyshidrosis (the GWAS Catalog's "Dyshidrosis (PheCode 705.1)"): 4 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 2,455 cases and 626,220 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 4 positions on this page: rs183433223 (TNIK), rs558850072 (TCERG1L), rs571769378 (DLG2), rs183168537 (PTPRD). PMID:39024449.
The 4 positions sit in or beside 4 genes: TNIK, TCERG1L, DLG2, PTPRD. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 10-12 — at rs183433223 in TNIK.
Read this page as a list of findings about Dyshidrosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Dyshidrosis is diagnosed by a clinician — not from a genotype. None of the 4 variants on this page is used by any guideline to predict, screen for or diagnose it.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Dyshidrosis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Dyshidrosis. MyGeneLog™. https://www.mygenelog.com/conditions/dyshidrosis
In the GWAS Catalog, Dyshidrosis is filed as "Dyshidrosis (PheCode 705.1)". Rather than define it, this page lists the genome-wide findings: 4 positions from 1 study, each with its study's sample and citation.
Genes play a part: 4 positions have been linked to it, the largest study recording 2,455 cases and 626,220 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 4 genes: TNIK, TCERG1L, DLG2, PTPRD. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Dyshidrosis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.