Acute Pancreatitis, as genome-wide studies have reported it: 6 positions from 3 studies, the largest recording 10,630 cases and 844,679 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
3 studies in the GWAS Catalog report 6 positions for Acute Pancreatitis, which the catalogue files as "Acute pancreatitis". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Bourgault J et al. 2023, in Gastroenterology — Proteome-Wide Mendelian Randomization Identifies Causal Links Between Blood Proteins and Acute Pancreatitis. The catalogue records its sample as 10,630 cases and 844,679 controls (European ancestry). From it, 4 positions on this page: rs12688091 (NUP62CL), rs12689287 (TBC1D8B), rs148849032 (STK32A-AS1), rs66491909 (RNF128). PMID:36736436.
Wang B et al. 2024, in Scientific Reports — Lipid levels and risk of acute pancreatitis using bidirectional Mendelian randomization. The catalogue records its sample as up to 14,112 European ancestry, Asian ancestry, African ancestry, Hispanic or Latin American cases, up to 1,032,106 European ancestry, Asian ancestry, African ancestry, Hispanic or Latin American controls. It contributes one position: rs142703147 (near SPINK1). PMID:38491158.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 11,855 cases and 615,017 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes one position: rs145959667 (near SPINK1). PMID:39024449.
The 6 positions sit in or beside 5 genes: NUP62CL, TBC1D8B, STK32A-AS1, RNF128, SPINK1. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Bourgault J et al. 2023 reported the smallest P value on this page — P = 6 × 10-19 — at rs12688091 in NUP62CL.
Read this page as a list of findings about Acute Pancreatitis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Acute Pancreatitis is diagnosed by a clinician — not from a genotype. None of the 6 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Acute Pancreatitis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Acute Pancreatitis. MyGeneLog™. https://www.mygenelog.com/conditions/acute-pancreatitis
Acute Pancreatitis is the condition the GWAS Catalog files under "Acute pancreatitis". This page does not define it in its own words; it lists what genome-wide studies have reported: 6 positions from 3 studies, with each study's sample and citation.
Genome-wide studies have reported 6 associated positions; the largest study behind this page recorded 10,630 cases and 844,679 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: NUP62CL, TBC1D8B, STK32A-AS1, RNF128, SPINK1. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Acute Pancreatitis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.