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Hip circumference adjusted for BMI

HLA-B · rs9378247

Where this position leads

Condition: Hip Circumference

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs9378247 Condition: Hip Circumference Hip Circumference Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs9378247 rs9378247 HLA-B

What the study found

Who was studied 186,825 British ancestry men.

The effect Each copy of the A allele shifted the measure 0.0265 lower (95% confidence interval 0.019-0.034); p = 3 × 10−11.

Where it sits Chromosome 6, band 6p21.33 — between genes, 0.2 kb from HLA-B.

What each result means

A/A Two copies of the version the research linked to Hip circumference adjusted for BMI. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Hip circumference adjusted for BMI. That is a smaller link than two copies.
G/G No copy of the version the research linked to Hip circumference adjusted for BMI. This is the starting point the study compared everyone against.
Source

Questions about rs9378247

What is rs9378247?

rs9378247 is a single position in the genome, in or near the HLA-B gene. Published research associates it with hip circumference adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs9378247 linked to?

On MyGeneLog this position is linked to Hip Circumference. The research behind each link, and its sources, are set out on that condition page.

Does rs9378247 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs9378247 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs9378247 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hip circumference adjusted for BMI (rs9378247). MyGeneLog™. https://www.mygenelog.com/variants/rs9378247

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