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Who was studied 450,243 European ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0604 higher (95% confidence interval 0.047-0.074); p = 2 × 10−18.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — between genes, 6.3 kb from HLA-B.
What each result means
C/CNo copy of the version the research linked to Appendicular lean mass. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Appendicular lean mass. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Appendicular lean mass. That is the strongest link of the three results. A link in a study is not a diagnosis.
Communications biology · 2020 · PMID 33097823 · open access
Questions about rs9265954
What is rs9265954?
rs9265954 is a single position in the genome, in or near the HLA-B gene. Published research associates it with appendicular lean mass. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs9265954 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs9265954 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs9265954 come from?
GWAS Catalog, Communications biology 2020, PMID:33097823. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Appendicular lean mass (rs9265954). MyGeneLog™. https://www.mygenelog.com/variants/rs9265954