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Substance use disorder

DPYD · rs79313673

Where this position leads

Condition: Substance Use Disorder

Drug: Fluoropyrimidines

rs79313673 Condition: Substance Use Disorder Substance Use Disorder Condition Drug: Fluoropyrimidines Fluoropyrimidines Drug rs79313673 rs79313673 DPYD

What the study found

Who was studied 1,458,999 European ancestry individuals, 240,296 African ancestry individuals, 58,370 mixed American ancestry individuals.

The effect The reported allele is T; the catalogue records no effect size ; p = 2 × 10−8.

Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD-AS1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Substance use disorder — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Substance use disorder.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Substance use disorder compared to the general population.
Source
Genome-wide meta-analyses of cross substance use disorders in diverse populations
Lai D, Zhang M, Green N, Abreu M, Schwantes-An TH, Parker CC, Zhang S, Jin F, Sun A, Zhang P, Edenberg HJ, Liu Y
and 1 more — show all
Foroud T
Molecular psychiatry · 2026 · PMID 41057643 · open access

Questions about rs79313673

What is rs79313673?

rs79313673 is a single position in the genome, in or near the DPYD gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs79313673 linked to?

On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.

Does rs79313673 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs79313673 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs79313673 come from?

GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Substance use disorder (rs79313673). MyGeneLog™. https://www.mygenelog.com/variants/rs79313673

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