G6PD · rs781865768
Where this position leads
Condition: G6PD Deficiency
Drugs: Dapsone, nitrofurantoin and other oxidising drugs, Hydroxychloroquine (Plaquenil) and chloroquine, Local anaesthetics (bupivacaine, lidocaine and others), Primaquine and tafenoquine, Rasburicase, Sulfamethoxazole and trimethoprim (Bactrim)
Strength of the evidence
ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What ClinVar records
Classification
Pathogenic for Anemia, nonspherocytic hemolytic, due to G6PD deficiency; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2026-01-27.
ClinVar record 1722699 NM_001360016.2(G6PD):c.595A>G (p.Ile199Val)
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
Source: ClinVar VCV001722699, criteria provided, multiple submitters, no conflicts
rs781865768 is a single position in the genome, in or near the G6PD gene. Published research associates it with anemia, nonspherocytic hemolytic, due to g6pd deficiency. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to G6PD Deficiency. The research behind each link, and its sources, are set out on that condition page.
G6PD carries pharmacogenomic findings for Dapsone, nitrofurantoin and other oxidising drugs, Hydroxychloroquine (Plaquenil) and chloroquine, Local anaesthetics (bupivacaine, lidocaine and others), Primaquine and tafenoquine, Rasburicase, Sulfamethoxazole and trimethoprim (Bactrim). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
ClinVar VCV001722699, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Anemia, nonspherocytic hemolytic, due to G6PD deficiency (rs781865768). MyGeneLog™. https://www.mygenelog.com/variants/rs781865768