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G6PD deficiency

G6PD · rs76723693

Where this position leads

Condition: G6PD Deficiency

Drugs: Dapsone, nitrofurantoin and other oxidising drugs, Hydroxychloroquine (Plaquenil) and chloroquine, Local anaesthetics (bupivacaine, lidocaine and others), Primaquine and tafenoquine, Rasburicase, Sulfamethoxazole and trimethoprim (Bactrim)

rs76723693 Condition: G6PD Deficiency G6PD Deficiency Condition Drug: Dapsone, nitrofurantoin and other oxidising drugs Dapsone, nitrofurantoin and other o… Drug Drug: Hydroxychloroquine (Plaquenil) and chloroquine Hydroxychloroquine (Plaquenil) and … Drug Drug: Local anaesthetics (bupivacaine, lidocaine and others) Local anaesthetics (bupivacaine, li… Drug Drug: Primaquine and tafenoquine Primaquine and tafenoquine Drug Drug: Rasburicase Rasburicase Drug Drug: Sulfamethoxazole and trimethoprim (Bactrim) Sulfamethoxazole and trimethoprim (… Drug rs76723693 rs76723693 G6PD

Strength of the evidence

3 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 2 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic/Likely pathogenic for G6PD deficiency, Anemia, nonspherocytic hemolytic, due to G6PD deficiency, Malaria, susceptibility to, G6PD-related disorder, Inborn genetic diseases and 1 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 24 submitters), last evaluated 2026-07-27. ClinVar record 10388 NM_001360016.2(G6PD):c.968T>C (p.Leu323Pro)

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version ClinVar lists as disease-causing or likely disease-causing for G6PD deficiency. This is the usual result. (ClinVar VCV000010388, criteria provided, multiple submitters, no conflicts)
A/G One copy of the version ClinVar lists as disease-causing or likely disease-causing for G6PD deficiency. Some conditions need only one copy; for others, one copy makes a person a carrier who is usually healthy but can pass it on. A genetic counsellor can say which applies. (ClinVar VCV000010388, criteria provided, multiple submitters, no conflicts)
G/G Two copies of the version ClinVar lists as disease-causing or likely disease-causing for G6PD deficiency. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. (ClinVar VCV000010388, criteria provided, multiple submitters, no conflicts)

Source: ClinVar VCV000010388, criteria provided, multiple submitters, no conflicts

Questions about rs76723693

What is rs76723693?

rs76723693 is a single position in the genome, in or near the G6PD gene. Published research associates it with g6pd deficiency. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs76723693 linked to?

On MyGeneLog this position is linked to G6PD Deficiency. The research behind each link, and its sources, are set out on that condition page.

Does rs76723693 affect how medicines work?

G6PD carries pharmacogenomic findings for Dapsone, nitrofurantoin and other oxidising drugs, Hydroxychloroquine (Plaquenil) and chloroquine, Local anaesthetics (bupivacaine, lidocaine and others), Primaquine and tafenoquine, Rasburicase, Sulfamethoxazole and trimethoprim (Bactrim). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs76723693 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs76723693 come from?

ClinVar VCV000010388, criteria provided, multiple submitters, no conflicts. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

G6PD deficiency (rs76723693). MyGeneLog™. https://www.mygenelog.com/variants/rs76723693

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