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Who was studied 47,079 British or unknown ancestry cases, 414,027 British or unknown ancestry controls; replicated in 98,298 cases, 247,446 controls.
The effect
Each copy of the G allele carried 1.10 times the odds of Mouth ulcers (95% confidence interval 1.08-1.11); p = 4 × 10−21.
How common The G allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.
What each result means
A/ANo copy of the version the research linked to Mouth ulcers. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Mouth ulcers. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Mouth ulcers. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2019 · PMID 30837455 · open access
Questions about rs76518703
What is rs76518703?
rs76518703 is a single position in the genome, in or near the HLA-B gene. Published research associates it with mouth ulcers. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs76518703 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs76518703 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs76518703 come from?
GWAS Catalog, Nature communications 2019, PMID:30837455. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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