Sensitive

DPYD c.2846A>T — fluoropyrimidine tolerance

DPYD · rs67376798

Where this position leads

Drug: Fluoropyrimidines

rs67376798 Drug: Fluoropyrimidines Fluoropyrimidines Drug rs67376798 rs67376798 DPYD

What each result means

A/A Two copies. Enzyme activity is substantially reduced and CPIC recommends a much lower dose or an alternative drug.
A/T One copy of DPYD c.2846A>T, which leaves the enzyme partly working rather than not at all. CPIC treats it as decreased function and recommends a reduced fluoropyrimidine starting dose with titration.
T/T No copy of this decreased-function variant.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.

Source: CPIC Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update, Clinical Pharmacology & Therapeutics (PMID 29152729).

Questions about rs67376798

What is rs67376798?

rs67376798 is a single position in the genome, in or near the DPYD gene. Published research associates it with dpyd c.2846a>t — fluoropyrimidine tolerance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs67376798 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs67376798 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs67376798 come from?

CPIC Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update, Clinical Pharmacology & Therapeutics (PMID 29152729). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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