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Classificationdrug response for Fluorouracil response, Inborn genetic diseases, tegafur response - Toxicity, capecitabine response - Toxicity, Dihydropyrimidine dehydrogenase deficiency and 4 more; reviewed by expert panel (3 of 4 stars, 18 submitters), last evaluated 2021-05-24.
ClinVar record 88974NM_000110.4(DPYD):c.2846A>T (p.Asp949Val)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
A/ATwo copies. Enzyme activity is substantially reduced and CPIC recommends a much lower dose or an alternative drug.
A/TOne copy of DPYD c.2846A>T, which leaves the enzyme partly working rather than not at all. CPIC treats it as decreased function and recommends a reduced fluoropyrimidine starting dose with titration.
T/TNo copy of this decreased-function variant.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.
Clinical pharmacology and therapeutics · 2018 · PMID 29152729
Questions about rs67376798
What is rs67376798?
rs67376798 is a single position in the genome, in or near the DPYD gene. Published research associates it with dpyd c.2846a>t — fluoropyrimidine tolerance. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs67376798 linked to?
On MyGeneLog this position is linked to Fluoropyrimidine Dosing (DPYD). The research behind each link, and its sources, are set out on that condition page.
Does rs67376798 affect how medicines work?
DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs67376798 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs67376798 come from?
CPIC Guideline for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing: 2017 Update, Clinical Pharmacology & Therapeutics (PMID 29152729). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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