Gene Knowledge Graph
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Feeling nervous

DPYD · rs6703588

Where this position leads

Condition: Irritable Mood

Drug: Fluoropyrimidines

rs6703588 Condition: Irritable Mood Irritable Mood Condition Drug: Fluoropyrimidines Fluoropyrimidines Drug rs6703588 rs6703588 DPYD

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Feeling nervous compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Feeling nervous.
G/G Published research associates this genotype with typical/baseline likelihood of Feeling nervous — no copies of the reported risk allele.
Source
Item-level analyses reveal genetic heterogeneity in neuroticism
Nagel M, Watanabe K, Stringer S, Posthuma D, van der Sluis S
Nature communications · 2018 · PMID 29500382 · open access

Questions about rs6703588

What is rs6703588?

rs6703588 is a single position in the genome, in or near the DPYD gene. Published research associates it with feeling nervous. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs6703588 linked to?

On MyGeneLog this position is linked to Irritable Mood. The research behind each link, and its sources, are set out on that condition page.

Does rs6703588 affect how medicines work?

DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs6703588 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs6703588 come from?

GWAS Catalog, Nat Commun 2018, PMID:29500382. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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