0 1511211Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others11Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 10,708 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 1.19 lower (95% confidence interval 1.11-1.27); p = 3 × 10−166.
How common The C allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in an intron of HLA-B.
What each result means
C/CTwo copies of the version the research linked to Serine protease 57 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Serine protease 57 levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Serine protease 57 levels. This is the starting point the study compared everyone against.
rs546481845 is a single position in the genome, in or near the HLA-B gene. Published research associates it with serine protease 57 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs546481845 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs546481845 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs546481845 come from?
GWAS Catalog, Science (New York, N.Y.) 2021, PMID:34648354. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 1511211Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple0China (ByteDance, Huawei, Baidu…)0Others11Total15Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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