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GZMB protein levels

HLA-B · rs41563615

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs41563615 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs41563615 rs41563615 HLA-B

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.38 higher (95% confidence interval 0.36-0.41); p = 3 × 10−233.

How common The T allele had a frequency of about 5% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

G/G Published research associates this genotype with typical/baseline likelihood of GZMB protein levels — no copies of the reported risk allele.
G/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with GZMB protein levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of GZMB protein levels compared to the general population.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs41563615

What is rs41563615?

rs41563615 is a single position in the genome, in or near the HLA-B gene. Published research associates it with gzmb protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs41563615 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs41563615 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs41563615 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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GZMB protein levels (rs41563615). MyGeneLog™. https://www.mygenelog.com/variants/rs41563615

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