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alpha-2-macroglobulin receptor-associated protein levels (LRPAP1.3640.14.3)

HLA-B · rs41552714

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs41552714 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs41552714 rs41552714 HLA-B

What the study found

Who was studied 3,301 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 1.81 higher (95% confidence interval 1.71-1.91); p = 1 × 10−240.

How common The A allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of alpha-2-macroglobulin receptor-associated protein levels (LRPAP1.3640.14.3) compared to the general population.
A/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with alpha-2-macroglobulin receptor-associated protein levels (LRPAP1.3640.14.3).
G/G Published research associates this genotype with typical/baseline likelihood of alpha-2-macroglobulin receptor-associated protein levels (LRPAP1.3640.14.3) — no copies of the reported risk allele.
Source
Genomic atlas of the human plasma proteome
Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR, Blackshaw J, Burgess S, Jiang T, Paige E, Surendran P, Oliver-Williams C, Kamat MA
and 21 more — show all
Prins BP, Wilcox SK, Zimmerman ES, Chi A, Bansal N, Spain SL, Wood AM, Morrell NW, Bradley JR, Janjic N, Roberts DJ, Ouwehand WH, Todd JA, Soranzo N, Suhre K, Paul DS, Fox CS, Plenge RM, Danesh J, Runz H, Butterworth AS
Nature · 2018 · PMID 29875488

Questions about rs41552714

What is rs41552714?

rs41552714 is a single position in the genome, in or near the HLA-B gene. Published research associates it with alpha-2-macroglobulin receptor-associated protein levels (lrpap1.3640.14.3). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs41552714 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs41552714 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs41552714 come from?

GWAS Catalog, Nature 2018, PMID:29875488. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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alpha-2-macroglobulin receptor-associated protein levels (LRPAP1.3640.14.3) (rs41552714). MyGeneLog™. https://www.mygenelog.com/variants/rs41552714

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