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Predicted platelet reactivity

HLA-B · rs3819288

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs3819288 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs3819288 rs3819288 HLA-B

What the study found

Who was studied 29,806 British ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.0835 lower (95% confidence interval 0.06-0.107); p = 1 × 10−12.

How common The C allele had a frequency of about 10% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of HLA-B.

What each result means

C/C Two copies of the version the research linked to Predicted platelet reactivity. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Predicted platelet reactivity. That is a smaller link than two copies.
T/T No copy of the version the research linked to Predicted platelet reactivity. This is the starting point the study compared everyone against.
Source

Questions about rs3819288

What is rs3819288?

rs3819288 is a single position in the genome, in or near the HLA-B gene. Published research associates it with predicted platelet reactivity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs3819288 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs3819288 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3819288 come from?

GWAS Catalog, Blood 2023, PMID:37647652. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Predicted platelet reactivity (rs3819288). MyGeneLog™. https://www.mygenelog.com/variants/rs3819288

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