Gene Knowledge Graph
UTC
Sensitive

Lucey-Driscoll syndrome

UGT1A1 · rs3755319

Where this position leads

Drugs: Atazanavir, Irinotecan, Sacituzumab govitecan (Trodelvy)

rs3755319 Drug: Atazanavir Atazanavir Drug Drug: Irinotecan Irinotecan Drug Drug: Sacituzumab govitecan (Trodelvy) Sacituzumab govitecan (Trodelvy) Drug rs3755319 rs3755319 UGT1A1

Strength of the evidence

1 / 4

ClinVar classifies it as disease-causing (or likely), reviewed at 0 of 4 stars.

How this is scored

4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.

What ClinVar records

Classification Pathogenic for Lucey-Driscoll syndrome; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2000-11-01. ClinVar record 12282 NC_000002.12:g.233758936=

Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version ClinVar lists as disease-causing for Lucey-Driscoll syndrome. A result like this should be confirmed by a medical genetic test and talked through with a doctor; consumer DNA files can misread rare variants. This call was sent to ClinVar without the lab's criteria, the least certain kind of record, so it may change. (ClinVar VCV000012282, no assertion criteria provided)

Source: ClinVar VCV000012282, no assertion criteria provided

Questions about rs3755319

What is rs3755319?

rs3755319 is a single position in the genome, in or near the UGT1A1 gene. Published research associates it with lucey-driscoll syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs3755319 affect how medicines work?

UGT1A1 carries pharmacogenomic findings for Atazanavir, Irinotecan, Sacituzumab govitecan (Trodelvy). That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs3755319 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3755319 come from?

ClinVar VCV000012282, no assertion criteria provided. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Licensed CC BY-NC 4.0: free to read, share and adapt for non-commercial use, naming MyGeneLog™ and linking the exact page. Commercial use, including training or serving a commercial AI system, needs a licence — https://www.mygenelog.com/license

Lucey-Driscoll syndrome (rs3755319). MyGeneLog™. https://www.mygenelog.com/variants/rs3755319

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