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Who was studied 5,358 Icelandic ancestry individuals.
The effect
Each copy of the A allele shifted the measure 1.26 higher (95% confidence interval 1.12-1.4); p = 7 × 10−71.
How common The A allele had a frequency of about 2% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in the 3′ untranslated region of HLA-B.
What each result means
A/ATwo copies of the version the research linked to Serum levels of protein PRSS57. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Serum levels of protein PRSS57. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Serum levels of protein PRSS57. This is the starting point the study compared everyone against.
Nature communications · 2022 · PMID 35078996 · open access
Questions about rs3177747
What is rs3177747?
rs3177747 is a single position in the genome, in or near the HLA-B gene. Published research associates it with serum levels of protein prss57. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs3177747 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs3177747 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs3177747 come from?
GWAS Catalog, Nature communications 2022, PMID:35078996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Serum levels of protein PRSS57 (rs3177747). MyGeneLog™. https://www.mygenelog.com/variants/rs3177747