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Waist-to-hip ratio adjusted for BMI

HLA-B · rs28752890

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs28752890 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs28752890 rs28752890 HLA-B

What the study found

Who was studied 219,872 British ancestry women.

The effect Each copy of the A allele shifted the measure 0.0211 higher (95% confidence interval 0.015-0.027); p = 2 × 10−12.

Where it sits Chromosome 6, band 6p21.33 — between genes, 18.4 kb from HLA-B.

What each result means

A/A Two copies of the version the research linked to Waist-to-hip ratio adjusted for BMI. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Waist-to-hip ratio adjusted for BMI. That is a smaller link than two copies.
G/G No copy of the version the research linked to Waist-to-hip ratio adjusted for BMI. This is the starting point the study compared everyone against.
Source

Questions about rs28752890

What is rs28752890?

rs28752890 is a single position in the genome, in or near the HLA-B gene. Published research associates it with waist-to-hip ratio adjusted for bmi. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs28752890 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs28752890 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs28752890 come from?

GWAS Catalog, Scientific reports 2021, PMID:34021172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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Waist-to-hip ratio adjusted for BMI (rs28752890). MyGeneLog™. https://www.mygenelog.com/variants/rs28752890

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