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Psoriasis

HLA-B · rs2596546

Where this position leads

Condition: Psoriasis

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs2596546 Condition: Psoriasis Psoriasis Condition Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs2596546 rs2596546 HLA-B

What the study found

Who was studied 20,105 European ancestry cases, 842,975 European ancestry controls.

The effect Each copy of the A allele shifted the measure 0.186 lower (95% confidence interval 0.15-0.22); p = 9 × 10−30.

How common The A allele had a frequency of about 65% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of HLA-B.

What each result means

A/A Two copies of the version the research linked to Psoriasis. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Psoriasis. That is a smaller link than two copies.
G/G No copy of the version the research linked to Psoriasis. This is the starting point the study compared everyone against.
Source
Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization
Liu S, Li L, Liang Y, Tan Y, Wang X, Feng Y, Chen N, Lei X
Briefings in bioinformatics · 2024 · PMID 39883516 · open access

Questions about rs2596546

What is rs2596546?

rs2596546 is a single position in the genome, in or near the HLA-B gene. Published research associates it with psoriasis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2596546 linked to?

On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.

Does rs2596546 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2596546 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2596546 come from?

GWAS Catalog, Briefings in bioinformatics 2024, PMID:39883516. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Psoriasis (rs2596546). MyGeneLog™. https://www.mygenelog.com/variants/rs2596546

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