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Who was studied 373,397 European ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.0151 higher (95% confidence interval 0.011-0.019); p = 8 × 10−13.
How common The C allele had a frequency of about 78% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in the 5′ untranslated region of HLA-B.
What each result means
C/CTwo copies of the version the research linked to Forced expiratory volume (baseline). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Forced expiratory volume (baseline). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Forced expiratory volume (baseline). This is the starting point the study compared everyone against.
Nature communications · 2025 · PMID 40374629 · open access
Questions about rs2596487
What is rs2596487?
rs2596487 is a single position in the genome, in or near the HLA-B gene. Published research associates it with forced expiratory volume (baseline). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs2596487 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs2596487 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs2596487 come from?
GWAS Catalog, Nature communications 2025, PMID:40374629. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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