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Sensitive

Diffuse diseases of connective (PheCode 709)

HLA-B · rs2523584

Where this position leads

Drugs: Abacavir, Allopurinol, Carbamazepine and oxcarbazepine

rs2523584 Drug: Abacavir Abacavir Drug Drug: Allopurinol Allopurinol Drug Drug: Carbamazepine and oxcarbazepine Carbamazepine and oxcarbazepine Drug rs2523584 rs2523584 HLA-B

What the study found

Who was studied 880 African American or Afro-Caribbean cases, 120,075 African American or Afro-Caribbean controls, 2,061 European ancestry cases, 446,273 European ancestry controls, 334 Hispanic or Latin American cases, 59,181 Hispanic or Latin American controls.

The effect Each copy of the A allele shifted the measure 0.443 lower (95% confidence interval 0.37-0.51); p = 3 × 10−13.

How common The A allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — in an intron of HLA-B.

What each result means

A/A Two copies of the version the research linked to Diffuse diseases of connective (PheCode 709). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Diffuse diseases of connective (PheCode 709). That is a smaller link than two copies.
G/G No copy of the version the research linked to Diffuse diseases of connective (PheCode 709). This is the starting point the study compared everyone against.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs2523584

What is rs2523584?

rs2523584 is a single position in the genome, in or near the HLA-B gene. Published research associates it with diffuse diseases of connective (phecode 709). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs2523584 affect how medicines work?

HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs2523584 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2523584 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Diffuse diseases of connective (PheCode 709) (rs2523584). MyGeneLog™. https://www.mygenelog.com/variants/rs2523584

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